diff --git a/ggml/src/ggml-cuda/mmq.cu b/ggml/src/ggml-cuda/mmq.cu
index 85692d4543..ceb95758d2 100644
--- a/ggml/src/ggml-cuda/mmq.cu
+++ b/ggml/src/ggml-cuda/mmq.cu
@@ -333,6 +333,28 @@ bool ggml_cuda_should_use_mmq(enum ggml_type type, int cc, int64_t ne11, int64_t
     }
 
     if (amd_wmma_available(cc)) {
+        // RDNA 4 is consistently worse on rocblas
+        // https://github.com/ggml-org/llama.cpp/pull/18537#issuecomment-3706422301
+        if (GGML_CUDA_CC_IS_RDNA3(cc)) {
+            // High expert counts almost always better on MMQ
+            // due to a large amount of graph splits
+            // https://github.com/ggml-org/llama.cpp/pull/18202
+            if (n_experts >= 64) {
+                return true;
+            }
+
+            switch (type) {
+                // These quants are really bad on MMQ
+                case GGML_TYPE_Q2_K:
+                case GGML_TYPE_Q6_K:
+                // These quants are usually worse but not always
+                case GGML_TYPE_IQ2_XS:
+                case GGML_TYPE_IQ2_S:
+                    return ne11 <= 128;
+                default:
+                    return true;
+            }
+        }
         return true;
     }