diff --git a/fastapi/_compat/model_field.py b/fastapi/_compat/model_field.py
index fa2008c5e..3b7dd6337 100644
--- a/fastapi/_compat/model_field.py
+++ b/fastapi/_compat/model_field.py
@@ -51,3 +51,15 @@ class ModelField(Protocol):
         exclude_defaults: bool = False,
         exclude_none: bool = False,
     ) -> Any: ...
+
+    def serialize_json(
+        self,
+        value: Any,
+        *,
+        include: Union[IncEx, None] = None,
+        exclude: Union[IncEx, None] = None,
+        by_alias: bool = True,
+        exclude_unset: bool = False,
+        exclude_defaults: bool = False,
+        exclude_none: bool = False,
+    ) -> bytes: ...
diff --git a/fastapi/_compat/v2.py b/fastapi/_compat/v2.py
index a17d62556..f3e8f4261 100644
--- a/fastapi/_compat/v2.py
+++ b/fastapi/_compat/v2.py
@@ -208,6 +208,27 @@ class ModelField:
             exclude_none=exclude_none,
         )
 
+    def serialize_json(
+        self,
+        value: Any,
+        *,
+        include: Union[IncEx, None] = None,
+        exclude: Union[IncEx, None] = None,
+        by_alias: bool = True,
+        exclude_unset: bool = False,
+        exclude_defaults: bool = False,
+        exclude_none: bool = False,
+    ) -> bytes:
+        return self._type_adapter.dump_json(
+            value,
+            include=include,
+            exclude=exclude,
+            by_alias=by_alias,
+            exclude_unset=exclude_unset,
+            exclude_defaults=exclude_defaults,
+            exclude_none=exclude_none,
+        )
+
     def __hash__(self) -> int:
         # Each ModelField is unique for our purposes, to allow making a dict from
         # ModelField to its JSON Schema.
diff --git a/fastapi/responses.py b/fastapi/responses.py
index 6c8db6f33..dd31e00ec 100644
--- a/fastapi/responses.py
+++ b/fastapi/responses.py
@@ -46,3 +46,15 @@ class ORJSONResponse(JSONResponse):
         return orjson.dumps(
             content, option=orjson.OPT_NON_STR_KEYS | orjson.OPT_SERIALIZE_NUMPY
         )
+
+
+class PydanticJSONResponse(JSONResponse):
+    """
+    JSON response using Pydantic v2's built-in JSON serialization
+    """
+
+    def render(self, content: Any) -> bytes:
+        assert isinstance(content, bytes), (
+            "PydanticJSONResponse must be used with a response model"
+        )
+        return content
diff --git a/fastapi/routing.py b/fastapi/routing.py
index 9be2b44bc..2cc96ab76 100644
--- a/fastapi/routing.py
+++ b/fastapi/routing.py
@@ -52,6 +52,7 @@ from fastapi.exceptions import (
     ResponseValidationError,
     WebSocketRequestValidationError,
 )
+from fastapi.responses import JSONResponse, PydanticJSONResponse, Response
 from fastapi.types import DecoratedCallable, IncEx
 from fastapi.utils import (
     create_cloned_field,
@@ -67,7 +68,6 @@ from starlette._utils import is_async_callable
 from starlette.concurrency import run_in_threadpool
 from starlette.exceptions import HTTPException
 from starlette.requests import Request
-from starlette.responses import JSONResponse, Response
 from starlette.routing import (
     BaseRoute,
     Match,
@@ -244,6 +244,7 @@ async def serialize_response(
     *,
     field: Optional[ModelField] = None,
     response_content: Any,
+    to_json: bool = False,
     include: Optional[IncEx] = None,
     exclude: Optional[IncEx] = None,
     by_alias: bool = True,
@@ -257,6 +258,7 @@ async def serialize_response(
         errors = []
         if not hasattr(field, "serialize"):
             # pydantic v1
+            assert not to_json, "PydanticJSONResponse requires a pydantic v2 model"
             response_content = _prepare_response_content(
                 response_content,
                 exclude_unset=exclude_unset,
@@ -282,6 +284,16 @@ async def serialize_response(
             )
 
         if hasattr(field, "serialize"):
+            if to_json:
+                return field.serialize_json(
+                    value,
+                    include=include,
+                    exclude=exclude,
+                    by_alias=by_alias,
+                    exclude_unset=exclude_unset,
+                    exclude_defaults=exclude_defaults,
+                    exclude_none=exclude_none,
+                )
             return field.serialize(
                 value,
                 include=include,
@@ -452,6 +464,7 @@ def get_request_handler(
                 content = await serialize_response(
                     field=response_field,
                     response_content=raw_response,
+                    to_json=issubclass(actual_response_class, PydanticJSONResponse),
                     include=response_model_include,
                     exclude=response_model_exclude,
                     by_alias=response_model_by_alias,
diff --git a/tests/test_pydantic_json_response_class.py b/tests/test_pydantic_json_response_class.py
new file mode 100644
index 000000000..e020f89a6
--- /dev/null
+++ b/tests/test_pydantic_json_response_class.py
@@ -0,0 +1,182 @@
+import math
+from typing import List, Optional
+
+import pytest
+from dirty_equals import IsFloatNan
+from fastapi import FastAPI
+from fastapi._compat import PYDANTIC_V2
+from fastapi.responses import PydanticJSONResponse
+from fastapi.testclient import TestClient
+from pydantic import BaseModel, Field
+
+from .utils import needs_py_lt_314, needs_pydanticv2
+
+app = FastAPI(default_response_class=PydanticJSONResponse)
+
+
+class CustomResponse(PydanticJSONResponse):
+    media_type = "application/x-custom"
+
+
+class Item(BaseModel):
+    name: str
+    price: float
+    category: str = Field("food", alias="CAT")
+    tax: float = 8.875
+    description: Optional[str] = None
+
+
+@app.get("/response-model", response_model=Item)
+@app.get(
+    "/response-model-include",
+    response_model=Item,
+    response_model_include={"name", "category"},
+)
+@app.get(
+    "/response-model-exclude",
+    response_model=Item,
+    response_model_exclude={"tax", "description"},
+)
+@app.get(
+    "/response-model-by-alias-false",
+    response_model=Item,
+    response_model_by_alias=False,
+)
+@app.get(
+    "/response-model-exclude-unset",
+    response_model=Item,
+    response_model_exclude_unset=True,
+)
+@app.get(
+    "/response-model-exclude-defaults",
+    response_model=Item,
+    response_model_exclude_defaults=True,
+)
+@app.get(
+    "/response-model-exclude-none",
+    response_model=Item,
+    response_model_exclude_none=True,
+)
+def get_response_model_params():
+    return {"name": "cheese", "price": 1.23, "tax": 8.875, "description": None}
+
+
+class FloatsNone(BaseModel):
+    # pydantic converts inf/nan to None by default
+    numbers: List[float]
+
+
+class FloatsNum(FloatsNone):
+    model_config = {"ser_json_inf_nan": "constants"}
+
+
+class FloatsStr(FloatsNone):
+    model_config = {"ser_json_inf_nan": "strings"}
+
+
+@app.get("/floats-none", response_model=FloatsNone)
+@app.get("/floats-num", response_model=FloatsNum)
+@app.get("/floats-str", response_model=FloatsStr)
+@app.get("/custom-class", response_class=CustomResponse, response_model=FloatsStr)
+def get_floats():
+    return {"numbers": [3.14, math.inf, math.nan, 2.72]}
+
+
+client = TestClient(app)
+
+
+@needs_pydanticv2
+@pytest.mark.parametrize(
+    "path,expected_response",
+    [
+        (
+            "/response-model",
+            {
+                "name": "cheese",
+                "price": 1.23,
+                "CAT": "food",
+                "tax": 8.875,
+                "description": None,
+            },
+        ),
+        ("/response-model-include", {"name": "cheese", "CAT": "food"}),
+        ("/response-model-exclude", {"name": "cheese", "price": 1.23, "CAT": "food"}),
+        (
+            "/response-model-by-alias-false",
+            {
+                "name": "cheese",
+                "price": 1.23,
+                "category": "food",
+                "tax": 8.875,
+                "description": None,
+            },
+        ),
+        (
+            "/response-model-exclude-unset",
+            {
+                "name": "cheese",
+                "price": 1.23,
+                "tax": 8.875,
+                "description": None,
+            },
+        ),
+        ("/response-model-exclude-defaults", {"name": "cheese", "price": 1.23}),
+        (
+            "/response-model-exclude-none",
+            {
+                "name": "cheese",
+                "price": 1.23,
+                "CAT": "food",
+                "tax": 8.875,
+            },
+        ),
+    ],
+)
+def test_response_model_params(path: str, expected_response: dict):
+    response = client.get(path)
+    assert response.status_code == 200
+    assert response.json() == expected_response
+
+
+@needs_pydanticv2
+@pytest.mark.parametrize(
+    "path,expected_numbers",
+    [
+        ("/floats-none", [3.14, None, None, 2.72]),
+        ("/floats-num", [3.14, math.inf, IsFloatNan, 2.72]),
+        ("/floats-str", [3.14, "Infinity", "NaN", 2.72]),
+    ],
+)
+def test_floats(path: str, expected_numbers: list):
+    response = client.get(path)
+    assert response.status_code == 200
+    assert response.json() == {"numbers": expected_numbers}
+
+
+@needs_pydanticv2
+def test_custom_response_class():
+    response = client.get("/custom-class")
+    assert response.status_code == 200
+    assert response.headers["content-type"] == "application/x-custom"
+    assert response.json() == {"numbers": [3.14, "Infinity", "NaN", 2.72]}
+
+
+@needs_py_lt_314
+def test_requires_pydantic_v2_model():
+    if PYDANTIC_V2:
+        from pydantic.v1 import BaseModel as BaseModelV1
+    else:
+        from pydantic import BaseModel as BaseModelV1
+
+    app = FastAPI(default_response_class=PydanticJSONResponse)
+
+    class ModelV1(BaseModelV1):
+        data: str
+
+    @app.get("/model-v1")
+    def get_model_v1() -> ModelV1:
+        return ModelV1(data="hello")
+
+    client = TestClient(app)
+    with pytest.raises(AssertionError, match="requires a pydantic v2 model"):
+        client.get("/model-v1")