diff --git a/fastapi/openapi/utils.py b/fastapi/openapi/utils.py
index 812003aee..910eca72f 100644
--- a/fastapi/openapi/utils.py
+++ b/fastapi/openapi/utils.py
@@ -339,6 +339,7 @@ def get_openapi_path(
                         )
                         callbacks[callback.name] = {callback.path: cb_path}
                 operation["callbacks"] = callbacks
+            status_code = "200"
             if route.status_code is not None:
                 status_code = str(route.status_code)
             else:
diff --git a/tests/test_openapi_custom_response_class_no_status_code.py b/tests/test_openapi_custom_response_class_no_status_code.py
new file mode 100644
index 000000000..18294f181
--- /dev/null
+++ b/tests/test_openapi_custom_response_class_no_status_code.py
@@ -0,0 +1,61 @@
+from starlette.responses import Response
+
+from fastapi import FastAPI
+from fastapi.testclient import TestClient
+from inline_snapshot import snapshot
+
+
+class CustomResponse(Response):
+    """A custom response class whose __init__ does not expose status_code
+    as a parameter with an int default. This previously caused an
+    UnboundLocalError during OpenAPI schema generation when the route
+    did not specify an explicit status_code."""
+
+    media_type = "text/plain"
+
+    def __init__(self, content: str, **kwargs: object) -> None:
+        super().__init__(content=content, status_code=200, **kwargs)
+
+
+app = FastAPI()
+
+
+@app.get("/items", response_class=CustomResponse)
+async def get_items():
+    return "ok"
+
+
+client = TestClient(app)
+
+
+def test_get_response():
+    response = client.get("/items")
+    assert response.status_code == 200
+    assert response.text == "ok"
+
+
+def test_openapi_schema():
+    """OpenAPI generation must not crash when the response class's __init__
+    lacks a status_code parameter with an int default."""
+    response = client.get("/openapi.json")
+    assert response.status_code == 200, response.text
+    assert response.json() == snapshot(
+        {
+            "openapi": "3.1.0",
+            "info": {"title": "FastAPI", "version": "0.1.0"},
+            "paths": {
+                "/items": {
+                    "get": {
+                        "summary": "Get Items",
+                        "operationId": "get_items_items_get",
+                        "responses": {
+                            "200": {
+                                "description": "Successful Response",
+                                "content": {"text/plain": {"schema": {"type": "string"}}},
+                            }
+                        },
+                    }
+                }
+            },
+        }
+    )